So, What is the Orlistat?
It is a drug designed for the treatment and prevention of obesity, this being understood as the excessive accumulation of fat. There are several classifications, however for practical purposes, according to the BMI (Body Mass Index) we have that a person can be with low weight, adequate weight, overweight, obesity type I, II, III, and IV.
Excess fat comes from inadequate nutrition, which does not accumulate in a day or a week, it is a result of constant abuse that may be years or months. It causes exhaustion and weakness, cardiovascular diseases, diabetes mellitus, sleep disorders, respiratory problems, arthritis, among other diseases.
In the intestines there is an enzyme called "Pancreatic Lipase" which is responsible for hydrolyzing triglycerides from food fatty acids to be absorbable and used as a source of energy for the rest of the body.
Orlistat acts locally at the level of the intestine, irreversibly inhibiting the activity of this enzyme. This prevents that at least 30% of the fatty acids from the intake are absorbed. It should be noted that only about 1% drug is absorbed, meaning that it does not enter the bloodstream or suffer the effects of the first step in the liver, so it is considered safe.
Studies have shown that it decreases cholesterol levels (it has been shown that it also inhibits 25% of its absorption), blood pressure, improves insulin resistance associated with Metabolic Syndrome and Polycystic Ovaries, since there is a decrease in fatty acids free in the system.